CDH11

In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration.

Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

• Cell membrane
• Single-pass type I membrane protein

Cad-11, Cdh11, Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin

• entrezGene:12552
• swissprot:P55288

Proteins

Oncology

88112Da