Cdh15
Domain
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Tissue Specificity
Skeletal muscle.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Cdh14, Cdh15, Cadherin-15, Cadherin-14, Muscle cadherin, M-cadherin