PCTAIRE1

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Post-translational modifications

Phosphorylation at Ser-153 inhibits kinase activity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Tissue specificity

Detected in pancreas islets (at protein level). Detected in brain and pancreas.

Cellular localization

• Cytoplasm
• Cytoplasmic vesicle
• Secretory vesicle
• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell junction
• Synapse
• Synaptosome
• Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Alternative names

• Cyclin-dependent kinase 16
• Cell division protein kinase 16
• PCTAIRE-motif protein kinase 1
• Serine/threonine-protein kinase PCTAIRE-1
• PCTK1
• PCTAIRE1
• CDK16

Database links

• swissprot:Q00536

Target type

Proteins

Primary research area

Oncology

Molecular weight

55716Da