CDKN2B

Function

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Sequence Similarities

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Tissue Specificity

Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

Cellular localization

• Cytoplasm
• Also found in the nucleus.

Alternative names

MTS2, CDKN2B, Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, MTS-2, p15INK4B

Database links

swissprot:P42772 omim:600431 swissprot:P42771 entrezGene:1029 entrezGene:1030