CDKN3

May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954).

Hepatocellular carcinoma

HCC

A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

None

The gene represented in this entry may be involved in disease pathogenesis.

Belongs to the protein-tyrosine phosphatase family.

• Cytoplasm
• Perinuclear region

CDI1, CIP2, KAP, CDKN3, Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase

• entrezGene:1033
• omim:123832
• swissprot:Q16667

Proteins

Oncology

23805Da