CDX1
Function
Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Sequence Similarities
Belongs to the Caudal homeobox family.
Tissue Specificity
Intestinal epithelium.
Cellular localization
- Nucleus
Alternative names
Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1