CEACAM3
Domain
The cytosolic domain is involved in S100A9 interaction.
Function
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Post-translational modifications
Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.
Tissue Specificity
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD66d, CD66D, CGM1, CEACAM3, Cell adhesion molecule CEACAM3, Carcinoembryonic antigen CGM1, Carcinoembryonic antigen-related cell adhesion molecule 3, CEA cell adhesion molecule 3