CEACAM3

The cytosolic domain is involved in S100A9 interaction.

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.

Belongs to the immunoglobulin superfamily. CEA family.

CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.

• Membrane
• Single-pass type I membrane protein

CD66d, CD66D, CGM1, CEACAM3, Cell adhesion molecule CEACAM3, Carcinoembryonic antigen CGM1, Carcinoembryonic antigen-related cell adhesion molecule 3, CEA cell adhesion molecule 3

• entrezGene:1084
• omim:609142
• swissprot:P40198

Proteins

Oncology

27091Da