CEACAM5

Function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).

(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Post-translational modifications

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Tissue specificity

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Apical cell membrane
• Cell surface
• Localized to the apical glycocalyx surface.

Alternative names

• Carcinoembryonic antigen-related cell adhesion molecule 5
• Carcinoembryonic antigen
• Meconium antigen 100
• CEA
• CEA
• CEACAM5

Database links

• entrezGene:1048
• entrezGene:634
• entrezGene:4680
• entrezGene:1084
• entrezGene:1089
• omim:109770
• omim:114890
• omim:163980
• swissprot:P06731
• swissprot:O75871
• swissprot:P13688
• swissprot:P40198
• swissprot:P40199

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

• Oncology

Molecular weight

76795Da