CEACAM5
GeneName
CEACAM5
Summary
CEACAM5, also known as CEA or carcinoembryonic antigen, is a 77 kDa glycoprotein predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract. It is localised to the apical and basolateral plasma membranes, as well as the extracellular region, and plays a vital role in cell-cell adhesion processes. CEACAM5 is involved in both homophilic and heterophilic cell-cell interactions, which are crucial for maintaining tissue architecture and function. Additionally, it has been implicated in the regulation of apoptotic processes and myotube differentiation, highlighting its multifaceted role in cellular dynamics.
Importance
CEACAM5 is relevant to: - Cancer research, particularly in colorectal cancer, as it is often overexpressed in tumours and serves as a potential biomarker for diagnosis and prognosis - Understanding cell adhesion mechanisms, which are fundamental in developmental biology and tissue integrity - Investigating the apoptotic processes, as it is involved in the negative regulation of apoptosis, which has implications in various diseases - Exploring its role in immune responses and interactions with pathogens, contributing to the broader understanding of host-pathogen dynamics
Top Products
For researchers investigating CEACAM5, we highly recommend the top-selling recombinant antibody, Anti-Carcino Embryonic Antigen CEA antibody [EPCEAR7] (ab133633). This antibody has been validated in knockout models, ensuring its reliability in various applications, including Western blotting (WB), immunohistochemistry (IHC), and immunocytochemistry (ICC). With 21 citations, it is well-regarded in the research community, making it an excellent choice for those seeking robust and consistent results in their studies of CEACAM5. The Anti-Carcino Embryonic Antigen CEA antibody [EPCEAR7] ELISA Kit (ab133633), supported by 21 citations, is an excellent option for researchers looking to accurately measure CEACAM5 levels in their samples.
Abcam Product Citation Summary
The use of the Abcam antibody ab99992 for detecting CEACAM5 in human serum suggests its relevance in studies related to serum biomarkers, potentially for diagnostic purposes.
Abcam Product Citation Table
Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Post-translational modifications
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.
Tissue Specificity
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Apical cell membrane
- Cell surface
- Localized to the apical glycocalyx surface.
Alternative names
CD66e, CEA, CEACAM5, Cell adhesion molecule CEACAM5, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium antigen 100, CEA cell adhesion molecule 5
Database links
swissprot:P06731 omim:109770 omim:114890 omim:163980 swissprot:O75871 swissprot:P13688 swissprot:P40198 swissprot:P40199 entrezGene:1048 entrezGene:634 entrezGene:4680 entrezGene:1084 entrezGene:1089
Other research areas
- Oncology