CEACAM5

Function

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Apical cell membrane
• Cell surface
• Localized to the apical glycocalyx surface.

Alternative names

• Psg30
• Cell adhesion molecule CEACAM5
• Carcinoembryonic antigen-related cell adhesion molecule 5
• Pregnancy-specific glycoprotein 30
• CEA cell adhesion molecule 5

Database links

• swissprot:Q3UKK2

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

106270Da