CEACAM8

The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:11590190, PubMed:2022629, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).

Glycosylated.

Belongs to the immunoglobulin superfamily. CEA family.

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Cell surface

CD66b, CGM6, CEACAM8, Cell adhesion molecule CEACAM8, CD67 antigen, Carcinoembryonic antigen CGM6, Carcinoembryonic antigen-related cell adhesion molecule 8, Non-specific cross-reacting antigen NCA-95, CEA cell adhesion molecule 8

• entrezGene:1088
• omim:615747
• swissprot:P31997

Proteins

Immunology & Infectious Disease

• Immuno-oncology

38154Da