CEACAM8

Domain

The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).

Post-translational modifications

Glycosylated.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Tissue specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Cell surface

Alternative names

• Carcinoembryonic antigen-related cell adhesion molecule 8
• CD67 antigen
• Carcinoembryonic antigen CGM6
• Non-specific cross-reacting antigen NCA-95
• CEACAM8
• CGM6

Database links

• entrezGene:1088
• omim:615747
• swissprot:P31997

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

38154Da