CEACAM8

Domain

The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:11590190, PubMed:2022629, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).

Post-translational modifications

Glycosylated.

Sequence Similarities

Belongs to the immunoglobulin superfamily. CEA family.

Tissue Specificity

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Cell surface

Alternative names

CD66b, CGM6, CEACAM8, Cell adhesion molecule CEACAM8, CD67 antigen, Carcinoembryonic antigen CGM6, Carcinoembryonic antigen-related cell adhesion molecule 8, Non-specific cross-reacting antigen NCA-95, CEA cell adhesion molecule 8

Database links

swissprot:P31997 omim:615747 entrezGene:1088

Other research areas

• Immuno-oncology