Cela2a
Function
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
Sequence Similarities
Belongs to the peptidase S1 family. Elastase subfamily.
Tissue Specificity
Highly expressed in pancreas (at mRNA and protein levels). Also expressed in adrenal gland and small intestine.
Cellular localization
- Secreted
Alternative names
Ela-2, Ela2, Ela2a, Chymotrypsin-like elastase family member 2A, Elastase-2, Elastase-2A