Cell division cycle-associated protein 2
Function
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Post-translational modifications
Phosphorylated by CDK1. May regulate its subcellular location.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Alternative names
Cell division cycle-associated protein 2, Recruits PP1 onto mitotic chromatin at anaphase protein, Repo-Man, CDCA2