The N-terminal and C-terminal disordered regions undergo liquid-liquid phase separation (LLPS) following homotetramerization and activation. Post-translational modifications, such as phosphorylation or lactylation affect the ability to undergo LLPS.
The nuclear export signal acts as a transcriptional repression domain. The TADI and TADII motifs (residues 17 to 25 and 48 to 56) correspond both to 9aaTAD motifs which are transactivation domains present in a large number of yeast and animal transcription factors.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. Positively regulates apoptosis in the early-stage embryo in response to UV irradiation (PubMed:15529176).
Belongs to the p53 family.
drp53, Cellular tumor antigen p53, Tumor suppressor p53
Proteins
Oncology
41899Da
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