CELSR2
Function
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Post-translational modifications
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Tissue Specificity
Highest expression in brain and testis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CDHF10, EGFL2, KIAA0279, MEGF3, CELSR2, Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, Epidermal growth factor-like protein 2, Flamingo homolog 3, Multiple epidermal growth factor-like domains protein 3, EGF-like protein 2, Multiple EGF-like domains protein 3