CEMIP2
Function
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments (PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity).
Sequence Similarities
Belongs to the CEMIP family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
KIAA1412, TMEM2, CEMIP2, Cell surface hyaluronidase CEMIP2, Cell migration-inducing hyaluronidase 2, Transmembrane protein 2