CENPH
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Sequence Similarities
Belongs to the CENP-H/MCM16 family.
Cellular localization
- Nucleus
- Chromosome
- Centromere
- Kinetochore
- Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
Alternative names
ICEN35, CENPH, Centromere protein H, CENP-H, Interphase centromere complex protein 35