CENPK
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Involvement in disease
Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.
Sequence Similarities
Belongs to the CENP-K/MCM22 family.
Tissue Specificity
Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
Cellular localization
- Nucleus
- Chromosome
- Centromere
- Chromosome
- Centromere
- Kinetochore
- Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Alternative names
ICEN37, FKSG14, CENPK, Centromere protein K, CENP-K, Interphase centromere complex protein 37, Protein AF-5alpha, p33