CENPM

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

• Nucleus
• Cytoplasm
• Chromosome
• Centromere
• Kinetochore
• Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres.

C22orf18, ICEN39, PANE1, CENPM, Centromere protein M, CENP-M, Interphase centromere complex protein 39, Proliferation-associated nuclear element protein 1

• entrezGene:79019
• omim:610152
• swissprot:Q9NSP4

Proteins

Immuno-oncology

19737Da