CENPQ
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).
Post-translational modifications
Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.
Sequence Similarities
Belongs to the CENP-Q/OKP1 family.
Cellular localization
- Nucleus
- Chromosome
- Centromere
- Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Alternative names
C6orf139, CENPQ, Centromere protein Q, CENP-Q