CCDC21

Function

Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

Sequence similarities

Belongs to the CEP85 family.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Cytoplasm
• Cytoskeleton
• Spindle pole
• Nucleus
• Nucleolus
• Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856).

Alternative names

• Centrosomal protein of 85 kDa
• Cep85
• Coiled-coil domain-containing protein 21
• CCDC21
• CEP85

Database links

• entrezGene:64793
• swissprot:Q6P2H3

Target type

Proteins

Molecular weight

85639Da