CERS5
Domain
The last loop motif confers selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor.
Function
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:31916624). Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity).
Pathway
Lipid metabolism; sphingolipid metabolism.
Post-translational modifications
Phosphorylated at the C-terminus by CK2.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
LASS5, CERS5, Ceramide synthase 5, CerS5, LAG1 longevity assurance homolog 5, Sphingoid base N-palmitoyltransferase CERS5, Sphingosine N-acyltransferase CERS5