CES3

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

N-glycosylated.

Belongs to the type-B carboxylesterase/lipase family.

Expressed in liver, colon and small intestine.

• Endoplasmic reticulum lumen

UNQ869/PRO1887, CES3, Carboxylesterase 3, Liver carboxylesterase 31 homolog

• entrezGene:23491
• omim:605279
• swissprot:Q6UWW8

Proteins

Metabolism

62282Da