CES3
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
Tissue Specificity
Expressed in liver, colon and small intestine.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
UNQ869/PRO1887, CES3, Carboxylesterase 3, Liver carboxylesterase 31 homolog