CETP
Function
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641, PubMed:3281933, PubMed:3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
Involvement in disease
Hyperalphalipoproteinemia 1
HALP1
A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Tissue Specificity
Expressed by the liver and secreted in plasma.
Cellular localization
- Secreted
- Secreted in plasma.
Alternative names
Cholesteryl ester transfer protein, Lipid transfer protein I, CETP