Cfb
Domain
The unliganded VWA domain has an inactive 'locked' conformation whereby the scissile Arg-256|Lys-257 bond is protected from proteolytic activation.
Function
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
Sequence Similarities
Belongs to the peptidase S1 family.
Cellular localization
- Secreted
Alternative names
Bf, H2-Bf, Cfb, Complement factor B, C3/C5 convertase