CFC_TACTR
Function
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms (PubMed:3512266). Its active form catalyzes the activation of clotting factor B (PubMed:3512266).
Post-translational modifications
N-glycosylated.
Lipopolysaccharide (LPS) activates clotting factor C by inducing the proteolytic cleavage of the clotting factor C light chain into clotting factor C chains A and B (PubMed:3308457, PubMed:3512266). Clotting factor C chains heavy, A and B remain associated via interchain disulfide bonds (PubMed:3512266).
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Expressed in hemocytes (at protein level).
Cellular localization
- Secreted
- Secreted in hemolymph (PubMed:2007602). Localizes in large granules of hemocytes (PubMed:2007602).
Alternative names
Clotting factor C, FC, Limulus factor C