CFD
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Involvement in disease
Complement factor D deficiency
CFDD
An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peptidase S1 family.
Cellular localization
- Secreted
Alternative names
DF, PFD, CFD, Complement factor D, Adipsin, C3 convertase activator, Properdin factor D