CGB3

Developmental stage

Expressed continuously during the whole pregnancy with a peak during the first trimester.

Function

Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Sequence Similarities

Belongs to the glycoprotein hormones subunit beta family.

Tissue Specificity

High expression in the placenta throughout pregnancy.

Cellular localization

• Secreted

Alternative names

CGB, CGB5, CGB8, CGB3, Choriogonadotropin subunit beta 3, Choriogonadotropin subunit beta, Chorionic gonadotropin chain beta, CG-beta

Database links

swissprot:P0DN86 omim:608826 omim:118860 omim:608824 omim:608825 entrezGene:94027 entrezGene:114336 entrezGene:93659 entrezGene:1082 swissprot:Q6NT52 swissprot:P0DN87 entrezGene:94115 swissprot:P01233 omim:608827