CGN
Domain
Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
Function
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Sequence Similarities
Belongs to the cingulin family.
Tissue Specificity
Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
Cellular localization
- Cell junction
- Tight junction
- Localizes to the apical junction complex composed of tight and adherens junctions (By similarity). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:12023291).
Alternative names
KIAA1319, CGN, Cingulin