CHAC1

Function

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Sequence Similarities

Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.

Cellular localization

• Cytoplasm
• Cytosol
• Golgi apparatus
• trans-Golgi network

Alternative names

BOTCH, CHAC1, Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Blocks Notch protein, Cation transport regulator-like protein 1, Botch

Database links

swissprot:Q9BUX1 entrezGene:79094 genbank:NP_077016 omim:614587