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CHAD

Function

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

Sequence Similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.

Tissue Specificity

Present in chondrocytes at all ages.

Cellular localization

Alternative names

SLRR4A, CHAD, Chondroadherin, Cartilage leucine-rich protein

swissprot:O15335 omim:602178 entrezGene:1101