CHAMP1
Function
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.
Post-translational modifications
Phosphorylated by CDK1. Mitotic phosphorylation is required for the attachment of spindle microtubules to the kinetochore.
Cellular localization
- Nucleus
- Chromosome
- Chromosome
- Centromere
- Kinetochore
- Cytoplasm
- Cytoskeleton
- Spindle
Alternative names
C13orf8, CAMP, CHAMP, KIAA1802, ZNF828, CHAMP1, Chromosome alignment-maintaining phosphoprotein 1, Zinc finger protein 828