CHD9
Function
Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).
Post-translational modifications
Phosphorylated on serine and tyrosine residues.
Sequence Similarities
Belongs to the SNF2/RAD54 helicase family.
Tissue Specificity
Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
KIAA0308, KISH2, PRIC320, AD-013, x0008, CHD9, Chromodomain-helicase-DNA-binding protein 9, CHD-9, ATP-dependent helicase CHD9, Chromatin-related mesenchymal modulator, Chromatin-remodeling factor CHROM1, Kismet homolog 2, PPAR-alpha-interacting complex protein 320 kDa, Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein, CReMM