CHGB
Function
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Post-translational modifications
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
O-glycosylated.
Sequence Similarities
Belongs to the chromogranin/secretogranin protein family.
Tissue Specificity
Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:37453717). Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
Cellular localization
- Secreted
- Neuroendocrine and endocrine secretory granules.
Alternative names
SCG1, CHGB, Secretogranin-1, Chromogranin-B, Secretogranin I, CgB, SgI