CHIT1

Function

Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity).

Sequence similarities

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

Tissue specificity

Highly expressed in tongue, stomach, kidney, brain, skin, testis, and bone marrow. Low level of expression was found in lung, heart, spleen, small intestine, and liver. Not detectable in pancreas, salivary gland, large intestine, uterus, or peripheral blood mononuclear cells (PBMC).

Cellular localization

• Secreted
• Lysosome
• A small proportion is lysosomal.

Alternative names

• Chitotriosidase-1
• Chitinase-1
• Chit1

Database links

• entrezGene:71884
• swissprot:Q9D7Q1

Target type

Proteins

Primary research area

Metabolism

Molecular weight

51112Da