CHODL
Function
May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen. B lymphocytes express isoform 2 only; peripheral blood T lymphocytes express isoform 3 only; granulocytes and monocytes express neither isoform 2 nor isoform 3. During development of T lymphocytes, bone marrow progenitor cells express isoform 2 only; thymocytes at different stages of maturation express predominantly isoform 2 and weakly isoform 3, and mature thymocytes express only isoform 2.
Cellular localization
- Cytoplasm
- Membrane
- Single-pass type I membrane protein
- Isoform 2
- Endoplasmic reticulum
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Isoform 3
- Cytoplasm
Alternative names
C21orf68, PRED12, UNQ872/PRO1890, CHODL, Chondrolectin, Transmembrane protein MT75