Chondrolectin
Developmental stage
During gestation (7dpc to 15 dpc) its expression is up-regulated. In 15 dpc embryo is expressed in muscle cells of heterogeneous origin, including those from tongue, trunk, and tail. In newborn mice localized to limb striated muscle cells. Expressed in myoblasts undergoing myogenic differentiation during proliferation and differentiation phases (PubMed:12711387). Expressed in spinal chord motor neurons at 10.5 dpc. Detected in the plexus region of the developing limb bud at 10.5 dpc and 11.5 dpc (PubMed:20437528).
Function
May play a role in the development of the nervous system such as in neurite outgrowth and elongation (PubMed:24067532). May be involved in motor axon growth and guidance (By similarity).
Tissue Specificity
In adult mice preferentially expressed in skeletal muscle, testis, brain, and lung. Expressed in striated muscle (at protein level). Expressed in spinal chord. Detected in spinal chord fast motor neurons (at protein level).
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Chondrolectin, Transmembrane protein MT75, Chodl