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CHPF

OverviewProducts

Function

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Sequence similarities

Belongs to the chondroitin N-acetylgalactosaminyltransferase family.

Tissue specificity

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.

Cellular localization

  • Isoform 1
  • Golgi apparatus
  • Golgi stack membrane
  • Single-pass type II membrane protein
  • Cytoplasm
  • Cytosol
  • Isoform 3
  • Cytoplasm
  • Cytosol
  • Mitochondrion
  • Isoform 2
  • Mitochondrion matrix

Alternative names

  • Chondroitin sulfate synthase 2
  • Chondroitin glucuronyltransferase 2
  • Chondroitin-polymerizing factor
  • Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
  • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
  • N-acetylgalactosaminyltransferase 2
  • ChPF
  • CHPF
  • CSS2
  • UNQ651/PRO1281

Database links

Target type

Proteins

Molecular weight

85467Da