CHPF

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization (PubMed:12716890).

Isoform 2

May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress.

Belongs to the chondroitin N-acetylgalactosaminyltransferase family.

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta.

Isoform 2

Expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.

Isoform 3

Also ubiquitous.

• Isoform 1
• Golgi apparatus
• Golgi stack membrane
• Single-pass type II membrane protein
• Cytoplasm
• Cytosol
• Isoform 3
• Cytoplasm
• Cytosol
• Mitochondrion
• Isoform 2
• Mitochondrion matrix

CSS2, UNQ651/PRO1281, CHPF, Chondroitin sulfate synthase 2, Chondroitin glucuronyltransferase 2, Chondroitin-polymerizing factor, Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II, N-acetylgalactosaminyltransferase 2, ChPF

• entrezGene:79586
• omim:610405
• swissprot:Q8IZ52

Proteins

Oncology

85467Da