CHRAC1
Function
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371).
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Cellular localization
- Nucleus
Alternative names
CHRAC15, CHRAC1, Chromatin accessibility complex protein 1, CHRAC-1, Chromatin accessibility complex 15 kDa protein, DNA polymerase epsilon subunit p15, CHRAC-15, HuCHRAC15