Chrd
Developmental stage
Detected at high levels in 7 dpc mouse embryos; its level decreases at later developmental stages and in adult tissues.
Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
Post-translational modifications
Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.
Sequence Similarities
Belongs to the chordin family.
Cellular localization
- Secreted
Alternative names
Chordin, Chrd