CHRD
Function
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).
Post-translational modifications
Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.
Sequence Similarities
Belongs to the chordin family.
Tissue Specificity
Expressed at the highest level in liver.
Cellular localization
- Secreted
Alternative names
UNQ217/PRO243, CHRD, Chordin