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Function

Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.

Cellular localization

  • Postsynaptic cell membrane
  • Multi-pass membrane protein
  • Cell membrane
  • Multi-pass membrane protein

Alternative names

Acra, Chrna1, Acetylcholine receptor subunit alpha

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

51939Da