CHST13

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

Belongs to the sulfotransferase 2 family.

Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.

• Golgi apparatus membrane
• Single-pass type II membrane protein

Carbohydrate sulfotransferase 13, Chondroitin 4-O-sulfotransferase 3, Chondroitin 4-sulfotransferase 3, C4ST-3, C4ST3, CHST13

• entrezGene:166012
• omim:610124
• swissprot:Q8NET6

Proteins

Immunology & Infectious Disease

38920Da