Chst5
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. May also have activity toward O-linked sugars of mucin-type acceptors.
Sequence Similarities
Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Tissue Specificity
Expressed in cornea.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
- Golgi membrane, early secretory pathway.
Alternative names
Gst4, Chst5, Carbohydrate sulfotransferase 5, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4, Intestinal N-acetylglucosamine-6-O-sulfotransferase, N-acetylglucosamine 6-O-sulfotransferase 3, GST4, I-GlcNAc6ST, Intestinal GlcNAc-6-sulfotransferase, mIGn6ST, GlcNAc6ST-3, Gn6st-3