cid
Function
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:11483958, PubMed:16839185). Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11483958, PubMed:16839185, PubMed:24703848). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:11483958, PubMed:16839185).
Sequence Similarities
Belongs to the histone H3 family.
Cellular localization
- Nucleus
- Chromosome
- Centromere
- Kinetochore
- Localizes exclusively in the kinetochore domain of centromeres. Co-expressed with yemalpha.
Alternative names
CENP-A, CG13329, cid, Histone H3-like centromeric protein cid, CENP-A homolog, Centromere identifier protein