KIAA1737/CIPC

Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.

• Nucleus
• Cytoplasm
• Cytosol
• Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol.

KIAA1737, CIPC, CLOCK-interacting pacemaker, CLOCK-interacting circadian protein

• entrezGene:85457
• swissprot:Q9C0C6

Proteins

Oncology

42692Da