CIR1
Function
May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Post-translational modifications
Phosphorylated by NEK6.
Tissue Specificity
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
Cellular localization
- Nucleus speckle
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Colocalizes with NEK6 in the centrosome.
Alternative names
CIR, CIR1, Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin