CKB
Domain
The internal MTS-like signal (iMTS-L) mediates targeting to mitochondria thermogenic fat cells.
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).
Post-translational modifications
Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome.
Sequence Similarities
Belongs to the ATP:guanido phosphotransferase family.
Cellular localization
- Cytoplasm
- Cytosol
- Mitochondrion
- Cell membrane
- Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region.
Alternative names
CKBB, CKB, Creatine kinase B-type, Brain creatine kinase, Creatine kinase B chain, Creatine phosphokinase B-type, B-CK, CPK-B