CKLF
Function
May play an important role in inflammation and regeneration of skeletal muscle (PubMed:11415443). Essential for embryonic development (By similarity).
Isoform 1
Has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:11415443). Binds CCR4 (PubMed:16137713).
Sequence Similarities
Belongs to the chemokine-like factor family.
Tissue Specificity
Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.
Cellular localization
- Isoform 1
- Secreted
- Isoform 2
- Membrane
- Multi-pass membrane protein
- Isoform 4
- Membrane
- Multi-pass membrane protein
Alternative names
CKLF1, HSPC224, UNQ410/PRO772, CKLF, Chemokine-like factor, C32