CKM

GeneName

CKM

Summary

CKM, also known as creatine kinase MB, M CK, or creatine kinase MM, is a 43 kDa enzyme predominantly expressed in cardiac and skeletal muscle tissues. It is localised in the cytosol and cytoplasm, with some presence in the extracellular space. CKM plays a vital role in energy metabolism by catalysing the reversible conversion of creatine and ATP to phosphocreatine and ADP, thereby facilitating the storage and transfer of high-energy phosphate groups during muscle contraction and recovery. Its activity is crucial for maintaining ATP levels in tissues with high energy demands.

Importance

CKM is relevant to: - Cardiac health, as it serves as a biomarker for myocardial infarction and other cardiac conditions due to its release into the bloodstream following cardiac injury. - Muscle disorders, where alterations in CKM levels can indicate muscle damage or disease. - Exercise physiology, as it plays a role in muscle energy metabolism and recovery during physical activity. - Research into metabolic diseases, where understanding CKM function may provide insights into energy metabolism dysregulation.

Top Products

For researchers investigating CKM, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Creatine Kinase MM antibody (ab174672), which is highly effective for Western blotting (WB) and has garnered 3 citations, reflecting its reliability in the field. Additionally, we offer the recombinant antibody, Anti-Creatine Kinase MM antibody [EPR25358-10] (ab283683), which provides the added benefits of batch-to-batch consistency and has been validated for multiple applications, including WB, immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC). This versatility makes it an excellent choice for researchers seeking dependable CKM detection across various experimental setups. The Anti-Creatine Kinase MM antibody ELISA Kit (ab110319) is an excellent option for researchers looking to measure CKM levels in their samples.

Abcam Product Citation Summary

The data indicates that the CKM target is being investigated in the context of myocarditis, specifically focusing on its levels in human Treg cells and their relationship with miR-146b and miR-155 expression. This suggests a potential role of CKM in immune responses related to cardiac inflammation.

Abcam Product Citation Table

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Sequence Similarities

Belongs to the ATP:guanido phosphotransferase family.

Cellular localization

• Cytoplasm

Alternative names

CKMM, CKM, Creatine kinase M-type, Creatine kinase M chain, Creatine phosphokinase M-type, M-CK, CPK-M

Database links

swissprot:P06732 entrezGene:1158 entrezGene:1152 swissprot:P12277 omim:123310