Clathrin light chain A

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).

Sequence Similarities

Belongs to the clathrin light chain family.

Cellular localization

• Cytoplasmic vesicle membrane
• Peripheral membrane protein
• Cytoplasmic side
• Membrane
• Coated pit
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasm
• Cytoskeleton
• Spindle
• Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.

Alternative names

Clathrin light chain A, Lca, CLTA

Database links

swissprot:P09496 omim:118960 omim:118970 swissprot:P09497 entrezGene:1211 entrezGene:1212